Although organic chemistry, from its early beginnings, has been mainly concerned with the systematic description of the chemical behavior of compounds, since the 1930s the subject has become increasingly “physical”. 1059 pp., hardcover € 82.50.-ISBN 1‐891‐38931‐9 Even in the study of organic chemistry, it is nowadays essential to have a comprehensive understanding of theoretical concepts and physical methods. University Science Books, Herndon, VA 2005. Angewandte Chemie International Edition Wiley One aspect of that is the development of many new However, since then, especially in the last two decades, physical‐organic chemistry has made enormous advances. The classic textbook Physical‐Organic Chemistry, by Neil Isaacs, which was published in 1987, provided a comprehensive treatment of the latest knowledge of the subject at that time. The understanding of the quantitative relationships between structure and reactivity properties of organic molecules that has come from such studies now forms a fundamental part of every basic lecture course. Evidence of that trend can be seen, for example, in the groundbreaking experimental studies of the mechanisms of fundamental processes such as S N 1 and S N 2 reactions (e.g., the work of Ingold and of Winstein), or in the development of the theory of pericyclic reactions (Woodward and Hoffman).
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